منابع مشابه
Transcription and Remodeling Produce Asymmetrically Unwrapped Nucleosomal Intermediates.
Nucleosomes are disrupted during transcription and other active processes, but the structural intermediates during nucleosome disruption in vivo are unknown. To identify intermediates, we mapped subnucleosomal protections in Drosophila cells using Micrococcal Nuclease followed by sequencing. At the first nucleosome position downstream of the transcription start site, we identified unwrapped int...
متن کاملtranscription initiation
Ve showed earlier [101 that the region of the bla promoter of Tn3 protected by the RHA-polymerase (REAP), has the normal size (about 60bp) at RJAP/promoter molar ratio r(2, but rises to about twice this extent as r increases. Ve confirm here that the species corresponding to normal and extended footprint distinguish by their electrophoretic mobilities. Furtheraore, inspection of the complexes b...
متن کاملChromatin: The nucleosome unwrapped
The structure of the nucleosome core particle has been determined by X-ray crystallography at 2.8 A resolution. The structure has several significant surprises, and provides important new insights into the structure and function of chromatin.
متن کاملMinireviewViews of Transcription Initiation
to bind both core and DNA (Figure 1). 2 is essentially identical to E. coli 2, with an exposed region 2.2 helix Initiation of transcription is the first step in gene expredicted to form a primary interface with core and the pression and a major point of regulation. Recent strucregion 2.3–2.4 helix, which recognizes the 10 element tural studies reveal the nature of the initiating complex and con...
متن کاملViews of Transcription Initiation
Initiation of transcription is the first step in gene expression and a major point of regulation. Recent structural studies reveal the nature of the initiating complex and suggest new ways of accomplishing the processes required for initiation.
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ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/483286a